DESCRIPTION:
5Flu-GFCPDHKAAMVLFLDSVYGIEVQDFLLHLLEVGFLP
NegativecontrolforfluoresceinDPc10peptide.
DPc10inactivepeptideisa36-residuepeptidethatdiffersfromDPc10(Gly2460-Pro2495,rabbit) atoneposition(R2475S)andrepresentsthesequenceofaknownCPVTmutantRYR2domain.ThispeptidebindsweaklyorfailstobindtotheDPc10interfaceanddoesNOTaffectchannelfunction.
DPc10inactiveinthecurrentformisnotcellpermeable.TheproductisusefulinapplicationsthatpermitaccesstoRYR2directly(viawholecellpatch,skinnedcells,blacklipidmembrane,vesicles,orupondeliverytocytoplasm).
ReadDPc10Publications ![]()
DATASHEET:
| Peptidename | FluoresceinDPc10InactivePeptide |
| Peptidesequence | 5Flu-GFCPDHKAAMVLFLDSVYGIEVQDFLLHLLEVGFLP |
| N-terminus | 5-Carboxyfluorescein |
| C-terminus | Acid |
| Counterions | Trifluroacetate(TFA) |
| Molecularweight | 4093.046 |
| HPLCanalysis | Analysiscarriedoutusinga100Å4.6x150mmcolumn,grADIentfrom10%-90%acetonitrile,in15minutes.60degC.Puritydeterminedas97% |
| MSanalysis | Molecularionpredicted:4393.046.Observed:4392.6[M+3H] |
| Appearance | Yellowpowderedsolid |
| Solubilisation | DMSO |
| Storage | Storeassuppliedat-20°Cforupto1year.Storedesiccated.Makefreshsolutionspriortouse. |
| Datasheet | A010-517 |
| MSDS | A010-517 |
| Notes | Theproductwaspurifiedinacetonitrileandwatercontaining0.1%trifluoroaceticacid(TFA)priortolyophilisation.Theproductwillthereforebepresentasitstrifluoroaceticacidsalt. |
| Regulatorystatement | Productforresearchuseonly.Notintendedfordiagnosticortherapeuticuse. |

